Catalyzed acyl halide-aldehyde cyclocondensations. New insights into the design of catalytic cross aldol reactions

被引：23

作者：

Nelson, SG ^{[1
]}

Wan, ZH ^{[1
]}

Peelen, TJ ^{[1
]}

Spencer, KL ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 36期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(99)01308-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substoichiometric quantities (2.5-20 mol%) of AI(SbF6)(3) catalyze the di(isopropyl)ethylamine-mediated cyclocondensation of various acyl halides and enolizable aldehydes to afford beta-lactones in good yields (58-93%). These reactions are discussed as a strategy for executing chemo- and regiospecific catalyzed cross aldol reactions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6535 / 6539

页数：5

共 16 条

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