Direct Amination of Azoles via Catalytic C-H, N-H Coupling

被引:345
作者
Monguchi, Daiki [1 ]
Fujiwara, Taiki [1 ]
Furukawa, Hirotoshi [1 ]
Mori, Atsunori [1 ]
机构
[1] Kobe Univ, Dept Sci & Chem Engn, Kobe, Hyogo 6578501, Japan
关键词
BOND FORMATION; DIRECT ARYLATION; ARYL HALIDES; EFFICIENT; FUNCTIONALIZATION; 2,5-DIARYLTHIAZOLE; BROMOTHIOPHENE; DERIVATIVES; AMIDATION; ACTIVATOR;
D O I
10.1021/ol900298e
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
C-H, N-H Coupling of azoles takes place with several amines in the presence of a copper catalyst to undergo amination at the 2-position. The reaction of benzothiazole with N-methylaniline in the presence of sodium acetate and 20 mol % Cu(OAc)(2) in xylene under an oxygen atmosphere afforded the aminated product in 81% yield.
引用
收藏
页码:1607 / 1610
页数:4
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