BOND FORMATION;
DIRECT ARYLATION;
ARYL HALIDES;
EFFICIENT;
FUNCTIONALIZATION;
2,5-DIARYLTHIAZOLE;
BROMOTHIOPHENE;
DERIVATIVES;
AMIDATION;
ACTIVATOR;
D O I:
10.1021/ol900298e
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
C-H, N-H Coupling of azoles takes place with several amines in the presence of a copper catalyst to undergo amination at the 2-position. The reaction of benzothiazole with N-methylaniline in the presence of sodium acetate and 20 mol % Cu(OAc)(2) in xylene under an oxygen atmosphere afforded the aminated product in 81% yield.