Stimulation of the 5-HT1A receptor selectively suppresses NMDA receptor-mediated synaptic excitation in the rat visual cortex

被引：36

作者：

Edagawa, Y ^{[1
]}

Saito, H ^{[1
]}

Abe, K ^{[1
]}

机构：

[1] Univ Tokyo, Fac Pharmaceut Sci, Dept Chem Pharmacol, Bunkyo Ku, Tokyo 1130033, Japan

来源：

BRAIN RESEARCH | 1999年 / 827卷 / 1-2期

关键词：

serotonin 5-HT1A receptor; 8-hydroxy-2-(N; N-dipropylamino)tetralin; (8-OH-DPAT); N-methyl-D-aspartate receptor; long-term potentiation; visual cortex;

D O I：

10.1016/S0006-8993(99)01300-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously found that stimulation of serotonin 5-MT,, receptors inhibits the induction of long-term potentiation (LTP) in the rat visual cortex. In the present study, the selective 5-HT1A receptor agonist 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT) significantly reduced N-methyl-D-aspartate (NMDA)) receptor-mediated synaptic responses recorded in Mg2+-free medium in rat Visual cortical slices. In addition, there was good correlation between the inhibitory effects of 8-OH-DPAT on MMDA responses and LTP. These results suggest that 5-HT1A receptor stimulation inhibits the induction of LTP by suppressing NMDA receptor-mediated synaptic excitation in the rat visual cortex. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：225 / 228

页数：4

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