Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors

被引：32

作者：

Birch, Alan M. ^{[1
]}

Kenny, Peter W. ^{[1
]}

Simpson, Iain ^{[1
]}

Whittamore, Paul R. O. ^{[1
]}

机构：

[1] AstraZeneca, Mereside, Macclesfield SK10 4TG, Cheshire, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Glycogen phosphorylase; Enzyme inhibitor; Diabetes; Matched molecular pair analysis; MMPA; Molecular editor; Cheminformatics; Leatherface; QSAR; QSPR; Physicochemical properties; Solubility; Plasma protein binding; Tetrazole; EFFICIENCY; SMILES; STATE;

D O I：

10.1016/j.bmcl.2008.12.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：850 / 853

页数：4

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