Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors

被引:32
作者
Birch, Alan M. [1 ]
Kenny, Peter W. [1 ]
Simpson, Iain [1 ]
Whittamore, Paul R. O. [1 ]
机构
[1] AstraZeneca, Mereside, Macclesfield SK10 4TG, Cheshire, England
关键词
Glycogen phosphorylase; Enzyme inhibitor; Diabetes; Matched molecular pair analysis; MMPA; Molecular editor; Cheminformatics; Leatherface; QSAR; QSPR; Physicochemical properties; Solubility; Plasma protein binding; Tetrazole; EFFICIENCY; SMILES; STATE;
D O I
10.1016/j.bmcl.2008.12.003
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Matched molecular pair analysis has been used in design of inhibitors of glycogen phosphorylase. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:850 / 853
页数:4
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