A closer look at proteolysis and MHC-class-II-restricted antigen presentation

被引：112

作者：

Lennon-Duménil, AM ^{[1
]}

Bakker, AH ^{[1
]}

Wolf-Bryant, P ^{[1
]}

Ploegh, HL ^{[1
]}

Lagaudrière-Gesbert, C ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(01)00293-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen presentation by MHC class 11 molecules relies on the action of endocytic proteases, which are differentially expressed in antigen-presenting cells and are regulated by different components of the immune system. Endocytic enzymes process and convert exogenous antigens into peptidic determinants capable of interaction with MHC class 11 molecules. Chemical and genetic tools have recently been developed to study the role of lysosomal proteases in antigen presentation.

引用

页码：15 / 21

页数：7

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