The use of zebrafish to understand immunity

被引：509

作者：

Trede, NS

Langenau, DM

Traver, D

Look, AT

Zon, LI

机构：

[1] Childrens Hosp, Dept Med, Div Hematol Oncol, Boston, MA 02115 USA

[2] Childrens Hosp, Howard Hughes Med Inst, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Div Pediat Oncol, Boston, MA 02115 USA

来源：

IMMUNITY | 2004年 / 20卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(04)00084-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For decades immunologists have relied heavily on the mouse model for their experimental designs. With the realization of the important role innate immunity plays in orchestrating immune responses, invertebrates such as worms and flies have been added to the repertoire. Here, we discuss the advent of the zebrafish as a powerful vertebrate model organism that promises to positively impact immunologic research.

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收藏

页码：367 / 379

页数：13

相关论文

共 92 条

[1] Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans [J].

Aballay, A ;

Yorgey, P ;

Ausubel, FM .

CURRENT BIOLOGY, 2000, 10 (23) :1539-1542

[2] Recognition of pathogen-associated molecular patterns by TLR family [J].

Akira, S ;

Hemmi, H .

IMMUNOLOGY LETTERS, 2003, 85 (02) :85-95

[3] Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis [J].

Alt, JR ;

Greiner, TC ;

Cleveland, JL ;

Eischen, CM .

EMBO JOURNAL, 2003, 22 (06) :1442-1450

[4] Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio [J].

Altmann, SM ;

Mellon, MT ;

Johnson, MC ;

Paw, BH ;

Trede, NS ;

Zon, LI ;

Kim, CH .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2004, 28 (04) :295-306

[5] Molecular and functional analysis of an interferon gene from the zebrafish, Danio rerio [J].

Altmann, SM ;

Mellon, MT ;

Distel, DL ;

Kim, CH .

JOURNAL OF VIROLOGY, 2003, 77 (03) :1992-2002

[6] A large-scale insertional mutagenesis screen in zebrafish [J].

Amsterdam, A ;

Burgess, S ;

Golling, G ;

Chen, WB ;

Sun, ZX ;

Townsend, K ;

Farrington, S ;

Haldi, M ;

Hopkins, N .

GENES & DEVELOPMENT, 1999, 13 (20) :2713-2724

[7] A forward-genetic approach for analysis of the immune system [J].

Appleby, MW ;

Ramsdell, F .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (06) :463-471

[8]

ARDAVIN CF, 1988, THYMUS, V11, P59

[9]

Beattie CE, 1999, METHODS CELL BIOL, V60, P71

[10] HIGH ABUNDANCE OF VIRUSES FOUND IN AQUATIC ENVIRONMENTS [J].

BERGH, O ;

BORSHEIM, KY ;

BRATBAK, G ;

HELDAL, M .

NATURE, 1989, 340 (6233) :467-468

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