Late-life anxiety and cognitive impairment: A review

被引:207
作者
Beaudreau, Sherry A.
O'Hara, Ruth
机构
[1] Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA
[2] Sierra Pacific MIRECC, Palo Alto, CA 94304 USA
基金
美国国家卫生研究院;
关键词
late-life anxiety; mild cognitive impairment; dementia; cognitive decline;
D O I
10.1097/JGP.0b013e31817945c3
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Emerging research implicates a consistent reciprocal relationship between late-life anxiety and cognition. Understanding this relationship may clarify pathophysiological substrates of cognitive impairment and why co-occurring anxiety and cognitive impairment relates to poorer treatment prognosis for both conditions. This article critically reviews evidence of more prevalent anxiety in cognitively impaired older adults, elevated anxiety related to poorer cognitive performance, and more severe anxiety symptoms predicting future cognitive decline. It considers pathophysiologic mediators and moderators, and the influence of comorbid depression or medical illness in anxiety. Identified directions for future research includes use of in-depth anxiety assessment comparing normal and mild cognitively impaired older adults and use of challenging neuropsychological tests to determine if specific cognitive domains suffer in anxious older adults.
引用
收藏
页码:790 / 803
页数:14
相关论文
共 81 条
[11]   Effects of anxiety versus depression on cognition in later life [J].
Bierman, EJM ;
Comijs, HC ;
Jonker, C ;
Beekman, ATF .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2005, 13 (08) :686-693
[12]   Five-factor personality dimensions, mood states, and cognitive performance in older adults [J].
Booth, Jane E. ;
Schinka, John A. ;
Brown, Lisa M. ;
Mortimer, James A. ;
Borenstein, Amy R. .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2006, 28 (05) :676-683
[13]   A distinctive interaction between chronic anxiety and problem solving in asymptomatic APOE e4 homozygotes [J].
Caselli, RJ ;
Reiman, EM ;
Hentz, JG ;
Osborne, D ;
Alexander, GE .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2004, 16 (03) :320-329
[14]  
Cohen GD, 1998, AM J GERIAT PSYCHIAT, V6, P1
[15]   Memory biases in the anxiety disorders: Current status [J].
Coles, ME ;
Heimberg, RG .
CLINICAL PSYCHOLOGY REVIEW, 2002, 22 (04) :587-627
[16]   Behavioral characterization of mild cognitive impairment [J].
Collie, A ;
Maruff, P ;
Currie, J .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2002, 24 (06) :720-733
[17]   THE NEUROPSYCHIATRIC INVENTORY - COMPREHENSIVE ASSESSMENT OF PSYCHOPATHOLOGY IN DEMENTIA [J].
CUMMINGS, JL ;
MEGA, M ;
GRAY, K ;
ROSENBERGTHOMPSON, S ;
CARUSI, DA ;
GORNBEIN, J .
NEUROLOGY, 1994, 44 (12) :2308-2314
[18]  
DELIS DC, 2001, DELISKAPLAN EXECUTIV
[19]   Comorbid anxiety disorder in late life depression: association with memory decline over four years [J].
DeLuca, AK ;
Lenze, EJ ;
Mulsant, BH ;
Butters, MA ;
Karp, JF ;
Dew, MA ;
Pollock, BG ;
Shear, MK ;
Houck, PR ;
Reynolds, CR .
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2005, 20 (09) :848-854
[20]   Anxiety in primary care [J].
Demertzis K.H. ;
Craske M.G. .
Current Psychiatry Reports, 2006, 8 (4) :291-297