The pheromone response pathway of Kluyveromyces lactis

被引：13

作者：

Coria, R ^{[1
]}

Kawasaki, L

Torres-Quiroz, F

Ongay-Larios, L

Sánchez-Paredes, E

Velázquez-Zavala, N

Navarro-Olmos, R

Rodríguez-González, M

Aguilar-Corachán, R

Coello, G

机构：

[1] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Genet Mol, Mexico City, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Unidad Computo, Mexico City, DF, Mexico

来源：

FEMS YEAST RESEARCH | 2006年 / 6卷 / 03期

关键词：

pheromone response; Kluyveromyces lactis; signal transduction; G-protein; yeast;

D O I：

10.1111/j.1567-1364.2005.00022.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mating pheromone response pathway in Saccharomyces cerevisiae is one of the best understood signalling pathways in eukaryotes. Comparison of this system with pathways in other fungal species has generated surprises and insights. Cloning and targetted disruption of genes encoding components of the pheromone response pathway has allowed the attribution of specific functions to these signal transduction components. In this review we describe current knowledge of the Kluyveromyces lactis mating system, and compare it with the well-understood S. cerevisiae pathway, emphasizing the similarities and differences in the heterotrimeric G protein activity. This mating pathway is controlled positively by both the G alpha and the G beta subunits of the heterotrimeric G protein.

引用

页码：336 / 344

页数：9

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