Rpr- and hid-driven cell death in Drosophila photoreceptors

被引：10

作者：

Hsu, CD ^{[1
]}

Adams, SM ^{[1
]}

O'Tousa, JE ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA

来源：

VISION RESEARCH | 2002年 / 42卷 / 04期

关键词：

rpr; hid; programmed cell death; apoptosis; photoreceptors; Drosophila;

D O I：

10.1016/S0042-6989(01)00231-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The reaper (rpr) and head involution defective (hid) genes mediate programmed cell death (PCD) during Drosophila development. We show that expression of either rpr or hid under control of a rhodopsin promoter induces rapid cell death of adult photoreceptor cells. Ultrastructural analysis revealed that the dying photoreceptor cells share morphological features with other cells undergoing PCD. The anti-apoptotic baculoviral P35 protein acts downstream of hid activity to suppress the photoreceptor cell death driven by rpr and hid. These results establish that the Drosophila photoreceptors are sensitive to the rpr- and hid-driven cell death pathways. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：507 / 516

页数：10

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