The enigma of caspase-2: the laymen's view

被引：100

作者：

Krumschnabel, G. ^{[1
]}

Sohm, B. ^{[1
]}

Bock, F. ^{[1
]}

Manzl, C. ^{[1
]}

Villunger, A. ^{[1
]}

机构：

[1] Innsbruck Med Univ, Div Dev Immunol, Bioctr, A-6020 Innsbruck, Austria

来源：

CELL DEATH AND DIFFERENTIATION | 2009年 / 16卷 / 02期

基金：

奥地利科学基金会; 欧盟第七框架计划;

关键词：

caspase-2; caspase activity; caspase activation platform; DNA damage; ER stress; PIDD; RAIDD; STRESS-INDUCED APOPTOSIS; CYTOCHROME-C RELEASE; PROTEIN-KINASE-C; NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; ETOPOSIDE-INDUCED APOPTOSIS; PROGRAMMED CELL-DEATH; MESSENGER-RNA; NUCLEAR-LOCALIZATION; MEDIATED APOPTOSIS;

D O I：

10.1038/cdd.2008.170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteolysis of cellular substrates by caspases (cysteine-dependent aspartate-specific proteases) is one of the hallmarks of apoptotic cell death. Although the activation of apoptotic caspases is considered a 'late-stage' event in apoptosis signaling, past the commitment stage, one caspase family member, caspase-2, splits the cell death community into half - those searching for evidence of an apical initiator function of this molecule and those considering it as an amplifier of the apoptotic caspase cascade, at best, if relevant for apoptosis at all. This review screens past and present biochemical as well as genetic evidence for caspase-2 function in cell death signaling and beyond.

引用

页码：195 / 207

页数：13

共 145 条

[61] Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization [J].

Lassus, P ;

Opitz-Araya, X ;

Lazebnik, Y .

SCIENCE, 2002, 297 (5585) :1352-1354

[62] Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis [J].

Lavrik, Inna N. ;

Golks, Alexander ;

Baumann, Simone ;

Krammer, Peter H. .

BLOOD, 2006, 108 (02) :559-565

[63] Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity [J].

LeBlanc, Philippe M. ;

Yeretssian, Garabet ;

Rutherford, Nancy ;

Doiron, Karine ;

Nadiri, Amal ;

Zhu, Lei ;

Green, Douglas R. ;

Gruenheid, Samantha ;

Saleh, Maya .

CELL HOST & MICROBE, 2008, 3 (03) :146-157

[64] Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells [J].

Lechardeur, D ;

Ming, X ;

Lukacs, GL .

JOURNAL OF CELL BIOLOGY, 2004, 167 (05) :851-862

[65] Protein kinase C ζ associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis [J].

Leroy, I ;

de Thonel, A ;

Laurent, G ;

Quillet-Mary, A .

CELLULAR SIGNALLING, 2005, 17 (09) :1149-1157

[66] Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation [J].

Lin, CF ;

Chen, CL ;

Chang, WT ;

Jan, MS ;

Hsu, LJ ;

Wu, RH ;

Fang, YT ;

Tang, MJ ;

Chang, WC ;

Lin, YS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (25) :23758-23765

[67] Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramide- and etoposide-induced apoptosis [J].

Lin, CF ;

Chen, CL ;

Chang, WT ;

Jan, MS ;

Hsu, LJ ;

Wu, RH ;

Tang, MJ ;

Chang, WC ;

Lin, YS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (39) :40755-40761

[68] DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis [J].

Liu, XS ;

Zou, H ;

Slaughter, C ;

Wang, XD .

CELL, 1997, 89 (02) :175-184

[69] Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene [J].

Logette, E ;

Solary, E ;

Corcos, L .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2005, 1738 (1-3) :1-5

[70] The human caspase-2 gene: alternative promoters, pre-mRNA splicing and AUG usage direct isoform-specific expression [J].

Logette, E ;

Wotawa, A ;

Solier, S ;

Desoche, L ;

Solary, E ;

Corcos, L .

ONCOGENE, 2003, 22 (06) :935-946

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