Enantioselective Friedel-Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme

被引：100

作者：

Wang, Changhao ^{[1
,2
]}

Li, Yinghao ^{[1
,2
]}

Jia, Guoqing ^{[1
]}

Liu, Yan ^{[1
]}

Lu, Shengmei ^{[1
]}

Li, Can ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Catalysis, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 50期

关键词：

BIS(OXAZOLINYL)PYRIDINE-SCANDIUM(III) TRIFLATE COMPLEXES; INTRAMOLECULAR G-QUADRUPLEX; K+ SOLUTION; ASYMMETRIC CATALYSIS; DEFICIENT CONDITIONS; ALKYLATION; SEQUENCE; PYRROLES; FORMS;

D O I：

10.1039/c2cc31320k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A human telomeric G-quadruplex (G4DNA) metalloenzyme, assembled with G4DNA and Cu2+ ions, can catalyze the enantioselective Friedel-Crafts (F-C) reaction in water with good enantioselectivity (up to 75% ee). Furthermore, we found that the absolute configuration and the enantioselectivity of the product largely depend on the conformation and the sequence of G4DNA.

引用

页码：6232 / 6234

页数：3

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