Estrogen and bone: Insights from estrogen-resistant, aromatase-deficient, and normal men

被引：52

作者：

Khosla, Sundeep ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Endocrine Res Unit, Rochester, MN 55905 USA

来源：

BONE | 2008年 / 43卷 / 03期

关键词：

sex steroids; osteoporosis; skeletal physiological; bone turnover;

D O I：

10.1016/j.bone.2008.05.005

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Findings from estrogen-resistant and aromatase-deficient men have provided important insights into the role of estrogen in the male skeleton during growth. importantly, as reported elsewhere in this issue, these data also suggested dose-response relationships between estrogen and bone turnover. In addition, studies in these unusual patients have stimulated research on defining the role of estrogen in regulating bone metabolism in normal adult and aging men, providing further insights into estrogen regulation of bone metabolism not only in men, but also in women. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：414 / 417

页数：4

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