A Bronsted acid and lewis base organocatalyst for the aza-Morita-Baylis-Hillman reaction

被引：120

作者：

Matsui, K ^{[1
]}

Takizawa, S ^{[1
]}

Sasai, H ^{[1
]}

机构：

[1] Osaka Univ, ISIR, Ibaraki, Osaka 5670047, Japan

来源：

SYNLETT | 2006年 / 05期

关键词：

enantioselective aza-Morita-Baylis-Hillman reaction; bifunctional catalyst; Bronsted acid; Lewis base; organocatalysis;

D O I：

10.1055/s-2006-933112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(S)-3-[2-(Diphenylphosphino)phenyl]BINOL has been established as an efficient asymmetric bifunctional organocatalyst for the aza-Morita-Baylis-Hillman (aza-MBH) reaction. The Bronsted acid and Lewis base functionalities cooperate in substrate activation to promote the reaction with high enantiocontrol.

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收藏

页码：761 / 765

页数：5

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