Kinetics of self-assembling microtubules: An ''inverse problem'' in biochemistry

被引:141
作者
Flyvbjerg, H
Jobs, E
Leibler, S
机构
[1] PRINCETON UNIV, DEPT PHYS, PRINCETON, NJ 08544 USA
[2] PRINCETON UNIV, DEPT MOLEC BIOL, PRINCETON, NJ 08544 USA
[3] RISO NATL LAB, DEPT OPT & FLUID DYNAM, DK-4000 ROSKILDE, DENMARK
关键词
D O I
10.1073/pnas.93.12.5975
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Experimental time series for a nonequilibrium reaction may in some cases contain sufficient data to determine a unique kinetic model for the reaction by a systematic mathematical analysis. As an example, a kinetic model for the self-assembly of microtubules is derived here from turbidity time series for solutions in which microtubules assemble. The model may be seen as a generalization of Oosawa's classical nucleation-polymerization model. it reproduces the experimental data with a four-stage nucleation process and a critical nucleus of 15 monomers.
引用
收藏
页码:5975 / 5979
页数:5
相关论文
共 18 条
  • [1] BERNE BJ, 1974, J MOL BIOL, V89, P737
  • [2] LATTICE-DEFECTS IN MICROTUBULES - PROTOFILAMENT NUMBERS VARY WITHIN INDIVIDUAL MICROTUBULES
    CHRETIEN, D
    METOZ, F
    VERDE, F
    KARSENTI, E
    WADE, RH
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 117 (05) : 1031 - 1040
  • [3] MODULATION OF THE DYNAMIC INSTABILITY OF TUBULIN ASSEMBLY BY THE MICROTUBULE-ASSOCIATED PROTEIN TAU
    DRECHSEL, DN
    HYMAN, AA
    COBB, MH
    KIRSCHNER, MW
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (10) : 1141 - 1154
  • [4] DURHAM ACH, 1971, NATURE-NEW BIOL, V229, P38
  • [5] DYSON F, 1976, STUDIES MATH PHYSICS
  • [6] THE ROLE OF SUBUNIT ENTROPY IN COOPERATIVE ASSEMBLY - NUCLEATION OF MICROTUBULES AND OTHER TWO-DIMENSIONAL POLYMERS
    ERICKSON, HP
    PANTALONI, D
    [J]. BIOPHYSICAL JOURNAL, 1981, 34 (02) : 293 - 309
  • [7] KINETICS OF SICKLE HEMOGLOBIN POLYMERIZATION .2. A DOUBLE NUCLEATION MECHANISM
    FERRONE, FA
    HOFRICHTER, J
    EATON, WA
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1985, 183 (04) : 611 - 631
  • [8] SPONTANEOUS NUCLEATION OF MICROTUBULES
    FYGENSON, DK
    FLYVBJERG, H
    SNEPPEN, K
    LIBCHABER, A
    LEIBLER, S
    [J]. PHYSICAL REVIEW E, 1995, 51 (05): : 5058 - 5063
  • [9] ROLE OF GTP HYDROLYSIS IN MICROTUBULE DYNAMICS - INFORMATION FROM A SLOWLY HYDROLYZABLE ANALOG, GMPCPP
    HYMAN, AA
    SALSER, S
    DRECHSEL, DN
    UNWIN, N
    MITCHISON, TJ
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (10) : 1155 - 1167
  • [10] LANDAU LD, 1976, COURSE THEORETICAL P, V1, P52