Prognostic molecular markers in cholangiocarcinoma: A systematic review

被引：74

作者：

Briggs, Christopher D. ^{[1
]}

Neal, Christopher P. ^{[1
]}

Mann, Christopher D. ^{[1
]}

Steward, William P. ^{[1
]}

Manson, Margaret M. ^{[1
]}

Berry, David P. ^{[2
]}

机构：

[1] Univ Leicester, Bioctr, Dept Canc Studies & Mol Med, Canc Biomarkers & Prevent Grp, Leicester LE1 7RH, Leics, England

[2] Univ Hosp Leicester, Leicester Gen Hosp, Dept Hepatobiliary & Pancreat Surg, Leicester LE5 4PW, Leics, England

来源：

EUROPEAN JOURNAL OF CANCER | 2009年 / 45卷 / 01期

基金：

英国医学研究理事会;

关键词：

Cholangiocarcinoma; Molecular markers; Prognosis; Survival; EXTRAHEPATIC BILE-DUCT; HUMAN INTRAHEPATIC CHOLANGIOCARCINOMA; FLUKE RELATED CHOLANGIOCARCINOMA; RESECTED BILIARY MALIGNANCIES; INVASIVE PAPILLARY CARCINOMAS; TUMOR-SUPPRESSOR P53; MASS-FORMING-TYPE; POOR-PROGNOSIS; CHOLANGIOCELLULAR CARCINOMA; PROTEIN EXPRESSION;

D O I：

10.1016/j.ejca.2008.08.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The worldwide incidence of cholangiocarcinoma (CC) is steadily rising, with the incidence in United Kingdom (UK) now exceeding 1000 cases per year. It is an aggressive malignancy typified by unresponsiveness to the existing chemotherapy and radiotherapy regimes in the vast majority of cases. Surgery offers the only hope of a cure, though post-operative disease recurrence is common, with 5-year survival rates of less than 25% following resection. Developments in molecular techniques and improved understanding of the basis of carcinogenesis in CC has led to examination of the role of biomarkers in predicting poor outcome. This systematic review examines published evidence relating to the prognostic significance of these molecular markers in CC. Of the molecular markers which have been investigated to date, p53 mutation, cyclins, proliferation indices, mucins, CA19-9, CRP and aneuploidy appear to hold significant potential as predictors of outcome in CC. These and other biomarkers may themselves represent novel therapeutic targets for CC. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：33 / 47

页数：15

共 157 条

[41] Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: Its relationship with a new morphological classification of cholangiocarcinoma [J].