Cationic peptides: Distribution and mechanisms of resistance

被引：135

作者：

Devine, DA ^{[1
]}

Hancock, REW ^{[1
]}

机构：

[1] Univ Leeds, Leeds Dent Inst, Div Oral Biol, Leeds LS2 9LU, W Yorkshire, England

来源：

CURRENT PHARMACEUTICAL DESIGN | 2002年 / 8卷 / 09期

关键词：

D O I：

10.2174/1381612023395501

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cationic antimicrobial peptides are observed throughout nature. In mammals they are observed both at epithelial surfaces and within the granules of phagocytic cells. They are an important component of innate defences, since in addition to their ability to kill microorganisms, they are able to modulate inflammatory responses. With respect to their ability to kill bacteria, it is very difficult to isolate resistant mutants. However there are a few known mechanisins of intrinsic resistance, including PhoPQ-dependent and other alterations in lipopolysaccharide structure that influence self promoted uptake, and protease-mediated resistance.

引用

页码：703 / 714

页数：12

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