Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase

被引：37

作者：

Alvarez, F

Ghérardi, A

Nebois, P

Sarciron, ME

Pétavy, AF

Walchshofer, N

机构：

[1] Univ Lyon 1, Fac Pharm, Chim Organ Lab, EA 635, F-69373 Lyon 08, France

[2] Univ Lyon 1, Fac Pharm, Parasitol Lab, EA 1887, F-69373 Lyon, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(02)00064-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ben zimidazole-4,7-diones derivatives substituted at 1- and/or 2-position have been synthetized and tested as inhibitors of purine nucleoside phosphorylase (PNP), isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：977 / 979

页数：3

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