Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

被引：88

作者：

Evans, GB

Furneaux, RH

Gainsford, GJ

Schramm, VL

Tyler, PC

机构：

[1] Ind Res Ltd, Carbohydrate Chem, Lower Hutt, New Zealand

[2] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 19期

基金：

美国国家卫生研究院;

关键词：

carbohydrate mimetics; enzyme inhibitors; nucleosides; purines;

D O I：

10.1016/S0040-4020(00)00194-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of the 'Immucillins', potent aza-C-nncleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3053 / 3062

页数：10

共 37 条

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