Lateralization of aminopeptidase A activity in substantia nigra, striatum and frontal cortex of rats

被引：7

作者：

Ramírez, MJ ^{[1
]}

Martínez, JM ^{[1
]}

Prieto, I ^{[1
]}

Alba, F ^{[1
]}

Ramírez, M ^{[1
]}

机构：

[1] Univ Jaen, Unit Physiol, Jaen 23071, Spain

来源：

NEUROPEPTIDES | 1999年 / 33卷 / 02期

关键词：

D O I：

10.1054/npep.1999.0011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several brain aminopeptidase activities have been reported to be asymmetrical, but no direct correlation with lateralized functions has been proposed. Cholecystokinin (CCK) coexists with dopamine (DA) in the nigrostriatal system, which is involved in lateralized motor behaviors. Because aminopeptidase A activity is probably responsible for the hydrolysis of CCK, we studied the left-right distribution of glutamate-(GluAP) and aspartate-aminopeptidase (AspAP) activities in their soluble (Sol) and membrane-bound (M-B) forms in the substantia nigra, striatum and cortex of rats. Although there was a highly significant predominance of the left side in the substantia nigra and striatum for Sol GluAP and M-B AspAP respectively, in the frontal cortex predominance was on the right side for M-B AspAP. These results suggest a relationship between aminopeptidase A activity and lateralized nigro-striato-cortical functions involving CCK.

引用

页码：155 / 158

页数：4

共 22 条

[11]

GLICK SD, 1983, HEMISYNDROMES PSYCHO, P7

[12] EVIDENCE FOR COEXISTENCE OF DOPAMINE AND CCK IN MESO-LIMBIC NEURONS [J].