PET radioligands targeting the brain GABAA/benzodiazepine receptor complex

被引：19

作者：

Andersson, Jan D. ^{[1
]}

Halldin, Christer ^{[1
]}

机构：

[1] Karolinska Inst, Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, Sweden

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷 / 3-4期

关键词：

F-18; GABA; benzodiazepine; radioligand; radiochemistry; POSITRON-EMISSION-TOMOGRAPHY; CENTRAL BENZODIAZEPINE-RECEPTORS; HEALTHY-HUMAN SUBJECTS; IN-VIVO; GABA(A)/BENZODIAZEPINE RECEPTOR; BIOLOGICAL EVALUATION; ELECTROPHILIC F-18; RO; 15-1788; BINDING; C-11;

D O I：

10.1002/jlcr.3008

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

The development of positron emission tomography radioligands for the GABAA/benzodiazepine receptor complex (GABAA receptor) labeled with 11C and 18F is examined. The review covers labeling strategies as well as brief biological evaluations of radioligands. In addition, we assess the special considerations that must be taken during a development program for radioligands targeting the GABAA receptor and explore some of the challenges that lie ahead. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：196 / 206

页数：11

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