A broad band of silence

被引：6

作者：

Smith, JS ^{[1
]}

Costello, JF ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

来源：

NATURE GENETICS | 2006年 / 38卷 / 05期

关键词：

D O I：

10.1038/ng0506-504

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aberrant methylation of a CpG island in cancer is thought to silence a single gene but not its neighbors. A new study in colon cancer shows that transcriptional silencing can also be unexpectedly diffuse, encompassing all the genes over the 4 Mb of chromosome band 2q14.2, marked by archipelagos of methylated islands and uniform heterochromatin modification.

引用

页码：504 / 506

页数：4

共 15 条

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