Engineering natural products using combinatorial biosynthesis and biocatalysis

被引：46

作者：

Zhou, Hui ^{[1
]}

Xie, Xinkai ^{[1
]}

Tang, Yi ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2008年 / 19卷 / 06期

关键词：

D O I：

10.1016/j.copbio.2008.10.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Many biologically active natural products are produced by the host organisms using dedicated biosynthetic pathways. The programming rules of these pathways may be rationally manipulated through combinatorial biosynthesis to produce natural products that contain structural variations or enhanced pharmacological properties. Furthermore, these pathways contain enzymes that can be harvested as powerful biocatalysts for the synthesis of both new drugs and existing blockbuster therapeutics. This review will highlight recent advances in exploring natural product biosynthetic pathways for new compounds, novel enzymes and useful biocatalysts.

引用

页码：590 / 596

页数：7

共 50 条

[1] Preparation of erythromycin analogs having functional groups at C-15 [J].

Ashley, Gary W. ;

Burlingame, Mark ;

Desai, Ruchir ;

Fu, Hong ;

Leaf, Tim ;

Licari, Peter J. ;

Tran, Chau ;

Abbanat, Darren ;

Bush, Karen ;

Macielag, Mark .

JOURNAL OF ANTIBIOTICS, 2006, 59 (07) :392-401

[2] Natural products to drugs: daptomycin and related lipopeptide antibiotics [J].

Baltz, RH ;

Miao, V ;

Wrigley, SK .

NATURAL PRODUCT REPORTS, 2005, 22 (06) :717-741

[3] Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans [J].

Bergmann, Sebastian ;

Schuemann, Julia ;

Scherlach, Kirstin ;

Lange, Corinna ;

Brakhage, Axel A. ;

Hertweck, Christian .

NATURE CHEMICAL BIOLOGY, 2007, 3 (04) :213-217

[4] Precursor-directed biosynthesis of epothilone in Escherichia coli [J].

Boddy, CN ;

Hotta, K ;

Tse, ML ;

Watts, RE ;

Khosla, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (24) :7436-7437

[5] Natural products to drugs: natural product-derived compounds in clinical trials [J].

Butler, Mark S. .

NATURAL PRODUCT REPORTS, 2008, 25 (03) :475-516

[6] Engineering Escherichia coli for production of functionalized terpenoids using plant P450s [J].

Chang, Michelle C. Y. ;

Eachus, Rachel A. ;

Trieu, William ;

Ro, Dae-Kyun ;

Keasling, Jay D. .

NATURE CHEMICAL BIOLOGY, 2007, 3 (05) :274-277

[7] AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].

CORTES, J ;

HAYDOCK, SF ;

ROBERTS, GA ;

BEVITT, DJ ;

LEADLAY, PF .

NATURE, 1990, 348 (6297) :176-178

[8] ENZYMATIC AND CHEMICAL MODIFICATIONS OF LIPOPEPTIDE ANTIBIOTIC A21978C - THE SYNTHESIS AND EVALUATION OF DAPTOMYCIN (LY146032) [J].

DEBONO, M ;

ABBOTT, BJ ;

MOLLOY, RM ;

FUKUDA, DS ;

HUNT, AH ;

DAUPERT, VM ;

COUNTER, FT ;

OTT, JL ;

CARRELL, CB ;

HOWARD, LC ;

BOECK, LD ;

HAMILL, RL .

JOURNAL OF ANTIBIOTICS, 1988, 41 (08) :1093-1105

[9] Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome [J].

Eustaquio, Alessandra S. ;

Moore, Bradley S. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (21) :3936-3938

[10] Salinosporamide A:: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora [J].

Feling, RH ;

Buchanan, GO ;

Mincer, TJ ;

Kauffman, CA ;

Jensen, PR ;

Fenical, W .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (03) :355-+

← 1 2 3 4 5 →