Total synthesis of altenuene and isoaltenuene

被引：50

作者：

Atemöller, M

Podlech, J

Fenske, D

机构：

[1] Univ Karlsruhe, TH, Inst Organ Chem, D-76131 Karlsruhe, Germany

[2] Univ Karlsruhe, Inst Anorgan Chem, TH, D-76131 Karlsruhe, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 07期

关键词：

mycotoxins; Suzuki coupling; biaryls; total synthesis; alternaria toxins;

D O I：

10.1002/ejoc.200500904

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of altenuene and isoaltenuene, toxins produced by various alternaria fungi, were achieved for the first time in ten steps, starting with quinic acid and commercially available acetal-protected phloroglucinic acid, with the longest linear sequence consisting of seven steps. The key reactions are palladium-catalyzed Suzuki-type couplings between an arene boronate and iodinated cyclohexenes. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006.

引用

收藏

页码：1678 / 1684

页数：7

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