Nanotechnologies for biomolecular detection and medical diagnostics

被引：350

作者：

Cheng, MMC

Cuda, G

Bunimovich, YL

Gaspari, M

Heath, JR

Hill, HD

Mirkin, CA

Nijdam, AJ

Terracciano, R

Thundat, T

Ferrari, M

机构：

[1] Ohio State Univ, Div Hematol & Oncol, Columbus, OH 43210 USA

[2] Univ Studi Magna Graecia, I-88100 Catanzaro, Italy

[3] CALTECH, Pasadena, CA 91125 USA

[4] Northwestern Univ, Int Inst Nanotechnol, Evanston, IL 60208 USA

[5] Northwestern Univ, Chem Dept, Evanston, IL 60208 USA

[6] Oak Ridge Natl Lab, Nanoscale Sci & Devices Grp, Oak Ridge, TN 37831 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2006年 / 10卷 / 01期

关键词：

D O I：

10.1016/j.cbpa.2006.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.

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收藏

页码：11 / 19

页数：9

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