Drugs With Anticholinergic Properties as a Risk Factor for Cognitive Impairment in Elderly People A Population-Based Study

被引：57

作者：

Cancelli, Iacopo ^{[1
]}

Gigli, Gian Luigi ^{[1
,2
]}

Piani, Antonella ^{[1
]}

Zanchettin, Barbara ^{[1
]}

Janes, Franceso ^{[1
,2
]}

Rinaldi, Adriana ^{[1
]}

Valente, Mariarosaria ^{[1
,2
]}

机构：

[1] Univ Udine, Sch Med, S Maria Miserocordia Univ Hosp, Dept Neurol, I-33100 Udine, Italy

[2] Univ Udine, Sch Med, Dept Expt & Clin Pathol & Med, I-33100 Udine, Italy

来源：

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | 2008年 / 28卷 / 06期

关键词：

D O I：

10.1097/JCP.0b013e31818ce849

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prevention of drug-related problems is a key issue in the aged. Anticholinergic (ACH) drugs are a biologically plausible and potentially modifiable risk factor for cognitive impairment. Therefore, we intended to evaluate the association between ACH drugs and cognitive impairment. Our study comprised 750 subjects aged 65 years or older. Cognitive impairment was evaluated using Mini-Mental State Examination and Global Deterioration Scale. Patients were classified into ACH-drug users and non-ACH-drug users. Those using ACH drugs (20.1%) were more likely to have cognitive impairment than those using non-ACH drugs (odds ratio, 3.18; 95% confidence interval, 1.93-5.23; P < 0.001); this association remained significant even after adjusting for potential confounding variables (odds ratio, 2.30; 95% confidence interval, 1.19-4.45). Our data suggest that ACH drug intake should be regarded a potentially modifiable risk factor for cognitive impairment in the elderly.

引用

页码：654 / 659

页数：6

共 27 条

[1] Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study [J].

Ancelin, ML ;

Artero, S ;

Portet, F ;

Dupuy, AM ;

Touchon, J ;

Ritchie, K .

BMJ-BRITISH MEDICAL JOURNAL, 2006, 332 (7539) :455-458

[2]

[Anonymous], 2014, International Statistical Classification of Diseases and Related Health Problems, 10th Revision, DOI DOI 10/2016/EN

[3] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[4] THE RISK OF ANTICHOLINERGIC TOXICITY IN THE ELDERLY - A STUDY OF PRESCRIBING PRACTICES IN 2 POPULATIONS [J].

BLAZER, DG ;

FEDERSPIEL, CF ;

RAY, WA ;

SCHAFFNER, W .

JOURNALS OF GERONTOLOGY, 1983, 38 (01) :31-35

[5] Long-term cognitive impact of anticholinergic medications in older adults [J].

Bottiggi, Kara A. ;

Salazar, Juan C. ;

Yu, Lei ;

Caban-Holt, Allison M. ;

Ryan, Melody ;

Mendiondo, Marta S. ;

Schmitt, Frederick A. .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2006, 14 (11) :980-984

[6] Drugs with anticholinergic properties as a risk factor for psychosis in patients affected by Alzheimer's disease [J].

Cancelli, I. ;

Valentinis, L. ;

Merlino, G. ;

Valente, M. ;

Gigli, G. L. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 84 (01) :63-68

[7] Factors associated with complex visual hallucinations during antidepressant treatment [J].

Cancelli, I ;

Marcon, G ;

Balestrieri, M .

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2004, 19 (08) :577-584

[8] Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women [J].

Cao, Y-J ;

Mager, D. E. ;

Simonsick, E. M. ;

Hilmer, S. N. ;

Ling, S. M. ;

Windham, B. G. ;

Crentsil, V. ;

Yasar, S. ;

Fried, L. P. ;

Abernethy, D. R. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 (03) :422-429

[9] The concurrent use of anticholinergics and cholinesterase inhibitors: Rare event or common practice? [J].

Carnahan, RM ;

Lund, BC ;

Perry, PJ ;

Chrischilles, EA .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2004, 52 (12) :2082-2087

[10] Serum anticholinergic activity and cognition in patients with moderate-to-severe dementia [J].

Chew, ML ;

Mulsant, BH ;

Pollock, BG .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2005, 13 (06) :535-538

← 1 2 3 →