Extracellular Vesicles and Autophagy in Osteoarthritis

被引：27

作者：

Gao, Tianyang ^{[1
,2
]}

Guo, Weimin ^{[1
]}

Chen, Mingxue ^{[1
]}

Huang, Jingxiang ^{[1
]}

Yuan, Zhiguo ^{[1
]}

Zhang, Yu ^{[1
]}

Wang, Mingjie ^{[1
]}

Li, Penghao ^{[1
]}

Peng, Jiang ^{[1
]}

Wang, Aiyuan ^{[1
]}

Wang, Yu ^{[1
]}

Sui, Xiang ^{[1
]}

Zhang, Li ^{[1
]}

Xu, Wenjing ^{[1
]}

Lu, Shibi ^{[1
]}

Zhang, Xifeng ^{[3
]}

Liu, Shuyun ^{[1
]}

Guo, Quanyi ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Regenerat Med Orthopaed, Inst Orthopaed, Key Lab Musculoskeletal Trauma & War Injuries, 28 Fuxing Rd, Beijing 100853, Peoples R China

[2] Shanxi Med Univ, 56 XinJiannan Rd, Taiyuan 030001, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Spine Div, Minimal Invas Spine Surg Ctr, Dept Orthopaed, 28 Fuxing Rd, Beijing 100853, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2016年 / 2016卷

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

ARTICULAR-CARTILAGE VESICLES; MATRIX VESICLES; CELL-DEATH; IN-VITRO; GROWTH; EXOSOMES; ACTIVATION; DISEASE; PROTEIN; MICROPARTICLES;

D O I：

10.1155/2016/2428915

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Osteoarthritis (OA) is a type of chronic joint disease that is characterized by the degeneration and loss of articular cartilage and hyperplasia of the synovium and subchondral bone. There is reasonable knowledge about articular cartilage physiology, biochemistry, and chondrocyte metabolism. However, the etiology and pathogenesis of OA remain unclear and need urgent clarification to guide the early diagnosis and treatment of OA. Extracellular vesicles (EVs) are small membrane-linking particles that are released from cells. In recent decades, several special biological properties have been found in EV, especially in terms of cartilage. Autophagy plays a critical role in the regulation of cellular homeostasis. Likewise, more and more research has gradually focused on the effect of autophagy on chondrocyte proliferation and function in OA. The synthesis and release of EV are closely associated with autophagy. At the same time, both EV and autophagy play a role in OA development. Based on the mechanism of EV and autophagy in OA development, EV may be beneficial in the early diagnosis of OA; on the other hand, the combination of EV and autophagy-related regulatory drugs may provide insight into possible OA therapeutic strategies.

引用

页数：8

共 66 条

[41]

Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins [J].