Expression and role of Fc- and complement-receptors on human dendritic cells

被引:55
作者
Bajtay, Z
Csomor, E
Sándor, N
Erdei, A
机构
[1] Eotvos Lorand Univ, Dept Immunol, H-1117 Budapest, Hungary
[2] Eotvos Lorand Univ, Hungarian Acad Sci, Res Grp, H-1117 Budapest, Hungary
关键词
Fc-receptors; complement-receptors; dendritic cell maturation; function;
D O I
10.1016/j.imlet.2005.11.023
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dendritic cells (DCs) are professional antigen presenting cells, which take up pathogens/foreign structures in peripheral tissues, then migrate to secondary lymphoid organs where they initiate adaptive immune responses by activating naive T-cells. In the early phase of antigen uptake pattern recognition receptors (including mannose-, scavenger- and toll-like receptors) that recognize pathogen-associated molecular patterns play an important role. Later receptors binding opsonized antigen are also involved in phagocytosis. These cell membrane molecules include various Fc-receptors, recognizing different isotypes of antibodies and various complement-receptors, such as CR3. CR4 and the C1q-binding complex of calreticulin and CD91. Here we aim to summarize how these immunecomplex binding receptors are involved in the initiation of DC maturation, and how they influence antigen presentation as well as some additional functions of these cells. (C) 2006 Published by Elsevier B.V.
引用
收藏
页码:46 / 52
页数:7
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