Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice

被引：51

作者：

Adzu, B ^{[1
]}

Amos, S ^{[1
]}

Dzarma, S ^{[1
]}

Wambebe, C ^{[1
]}

Gamaniel, K ^{[1
]}

机构：

[1] Natl Inst Pharmaceut R&D, Dept Pharmacol & Toxicol, Abuja, Nigeria

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2002年 / 79卷 / 01期

关键词：

exploratory behaviour; spontaneous motor activity; motor coordination; pentobarbital sleep;

D O I：

10.1016/S0378-8741(01)00348-8

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effects of the aqueous extract of Zizypus sphina-christi Willd root bark against exploratory behaviour, spontaneous motor activity (SMA), motor coordination (Rota-rod performance) and pentobarbital-induced hypnosis were investigated in mice. The extract induced a significant (P < 0.05) dose-dependent reduction in exploratory behaviour and SMA when administered orally. It also prolonged pontobarbital sleeping time but failed to inhibit motor coordination (rota-rod performance) in the experimental mice. These results suggest that the extract contained sonic Constituents that depress the central nervous system, which may not be due to neuromuscular blockade. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：13 / 16

页数：4

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