Melanopsin: Another way of signaling light

被引：93

作者：

Peirson, S ^{[1
]}

Foster, RG ^{[1
]}

机构：

[1] Charing Cross Hosp, Imperial Coll London, Fac Med, Dept Cellular & Mol Neurosci,Div Neurosci & Menta, London W6 8RF, England

来源：

NEURON | 2006年 / 49卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.neuron.2006.01.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A subset of melanopsin-expressing retinal ganglion cells has been identified to be directly photosensitive (pRGCs), modulating a range of behavioral and physiological responses to light. Recent expression studies of melanopsin have provided compelling evidence that melanopsin is the photopigment of the pRGCs. However, the mechanism by which melanopsin tranduces light information remains an open question. This review discusses the signaling pathways that may underlie melanopsin-dependent phototransduction in native pRGCs, as well as the many exciting challenges ahead.

引用

页码：331 / 339

页数：9

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