Melanopsin: Another way of signaling light

被引：93

作者：

Peirson, S ^{[1
]}

Foster, RG ^{[1
]}

机构：

[1] Charing Cross Hosp, Imperial Coll London, Fac Med, Dept Cellular & Mol Neurosci,Div Neurosci & Menta, London W6 8RF, England

来源：

NEURON | 2006年 / 49卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.neuron.2006.01.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A subset of melanopsin-expressing retinal ganglion cells has been identified to be directly photosensitive (pRGCs), modulating a range of behavioral and physiological responses to light. Recent expression studies of melanopsin have provided compelling evidence that melanopsin is the photopigment of the pRGCs. However, the mechanism by which melanopsin tranduces light information remains an open question. This review discusses the signaling pathways that may underlie melanopsin-dependent phototransduction in native pRGCs, as well as the many exciting challenges ahead.

引用

页码：331 / 339

页数：9

共 85 条

[51] G protein pathways [J].

Neves, SR ;

Ram, PT ;

Iyengar, R .

SCIENCE, 2002, 296 (5573) :1636-1639

[52] Melanopsin forms a functional short-wavelength photopigment [J].

Newman, LA ;

Walker, MT ;

Brown, RL ;

Cronin, TW ;

Robinson, PR .

BIOCHEMISTRY, 2003, 42 (44) :12734-12738

[53] Illumination of the melanopsin signaling pathway [J].

Panda, S ;

Nayak, SK ;

Campo, B ;

Walker, JR ;

Hogenesch, JB ;

Jegla, T .

SCIENCE, 2005, 307 (5709) :600-604

[54] Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting [J].

Panda, S ;

Sato, TK ;

Castrucci, AM ;

Rollag, MD ;

DeGrip, WJ ;

Hogenesch, JB ;

Provencio, I ;

Kay, SA .

SCIENCE, 2002, 298 (5601) :2213-2216

[55] Mix and match color vision: Tuning spectral sensitivity by differential opsin gene expression in Lake Malawi Cichlids [J].

Parry, JWL ;

Carleton, KL ;

Spady, T ;

Carboo, A ;

Hunt, DM ;

Bowmaker, JK .

CURRENT BIOLOGY, 2005, 15 (19) :1734-1739

[56] Mammalian photoentrainment: Results, methods, and approaches [J].

Peirson, SN ;

Thompson, S ;

Hankins, MW ;

Foster, RG .

CIRCADIAN RHYTHMS, 2005, 393 :697-+

[57] Recent advances in our understanding of rhodopsin and phototransduction [J].

Pepe, IM .

PROGRESS IN RETINAL AND EYE RESEARCH, 2001, 20 (06) :733-759

[58] Anatomy: Photoreceptive net in the mammalian retina - This mesh of cells may explain how some blind mice can still tell day from night. [J].

Provencio, I ;

Rollag, MD ;

Castrucci, AM .

NATURE, 2002, 415 (6871) :493-493

[59] VISUAL AND CIRCADIAN RESPONSES TO LIGHT IN AGED RETINALLY DEGENERATE MICE [J].

PROVENCIO, I ;

WONG, SY ;

LEDERMAN, AB ;

ARGAMASO, SM ;

FOSTER, RG .

VISION RESEARCH, 1994, 34 (14) :1799-1806

[60]

Provencio I, 1998, J COMP NEUROL, V395, P417, DOI 10.1002/(SICI)1096-9861(19980615)395:4<417::AID-CNE1>3.0.CO

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