In vitro synergy testing of clarithromycin and 14-hydroxyclarithromycin with amoxicillin or bismuth subsalicylate against Helicobacter pylori

被引：14

作者：

Meyer, JM

Ryu, S

Pendland, SL

Danziger, LH

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT PHARM PRACTICE,CHICAGO,IL 60612

[2] UNIV ILLINOIS,COLL MED,CHICAGO,IL 60612

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 07期

关键词：

D O I：

10.1128/AAC.41.7.1607

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activity of clarithromycin-14-hydroxyclarithromycin (2:1 ratio) and bismuth subsalicylate or amoxicillin against Helicobacter pylori was determined by the checkerboard technique in vitro. Clarithromycin-14-hydroxyclarithromycin and amoxicillin resulted in additive effects in 7 of 22 isolates, compared to 14 of 22 isolates when bismuth subsalicylate was substituted for amoxicillin. Synergy was not demonstrated and is probably not responsible for the clinical success of treatment combinations containing clarithromycin.

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页码：1607 / 1608

页数：2

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