Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia

被引：44

作者：

Chen, Wenliang

Tang, Weidong

Lou, Liguang

Zhao, Weimin

机构：

[1] Chinese Acad Sci, Dept Nat Prod Chem, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China

来源：

PHYTOCHEMISTRY | 2006年 / 67卷 / 10期

关键词：

Helicteres angustifolia; Sterculiaceae; pregnane; coumarin; triterpenoid; cytotoxicity;

D O I：

10.1016/j.phytochem.2006.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2 alpha,7 beta,20 alpha-Trihydroxy-3 beta,21-dimethoxy-5-pregnene (1), 6,7,9 alpha-trihydroxy-3,8, 11 alpha-trimethyleyclohexo-[d,e]-coumarin (2), 3 beta-phy-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid (3), and 3 beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid methyl ester (4), along with 24 known compounds were isolated and structurally characterized from roots and aerial parts of Helicteres angustifolia (Sterculiaceae). In a preliminary bioassay, the two cucurbitacin derivatives, cucurbitacin D and J exhibited significant inhibitory activities against the growth of both hepatocellular carcinoma BEL-7402 cells and malignant melanoma SK-MEL-28 cells in vitro. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1041 / 1047

页数：7

共 27 条

[1] Flavonol glycosides from the seed coat of a new manteca-type dry bean (Phaseolus vulgaris L.) [J].

Beninger, CW ;

Hosfield, GL .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (08) :2906-2910

[2] 8-HYDROXYFLAVONOID GLUCURONIDES FROM MALVA-SYLVESTRIS [J].

BILLETER, M ;

MEIER, B ;

STICHER, O .

PHYTOCHEMISTRY, 1991, 30 (03) :987-990

[3] Analysis of three lupane type triterpenoids in Helicteres angustifolia by high-performance liquid chromatography [J].

Chang, YS ;

Ku, YR ;

Lin, JH ;

Lu, KL ;

Ho, LK .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2001, 26 (5-6) :849-855

[4] CONSTITUENTS OF FORMOSAN ANTITUMOR FOLK MEDICINE .3. A MANSONONE FROM HELICTERES-ANGUSTIFOLIA [J].

CHEN, CM ;

CHEN, ZT ;

HONG, YL .

PHYTOCHEMISTRY, 1990, 29 (03) :980-982

[5]

Chiu N. Y., 1995, ILLUSTRATED MED PLAN, P104

[6] Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells [J].

Duncan, KLK ;

Duncan, MD ;

ALley, MC ;

Sausville, EA .

BIOCHEMICAL PHARMACOLOGY, 1996, 52 (10) :1553-1560

[7]

FONSECA S F, 1978, Phytochemistry (Oxford), V17, P499, DOI 10.1016/S0031-9422(00)89347-4

[8]

Fukuyama Y, 1996, CHEM PHARM BULL, V44, P1418, DOI 10.1248/cpb.44.1418

[9]

GALLILY B, 1962, CANCER RES, V22, P1038

[10]

GITTER S, 1961, CANCER RES, V21, P516

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