Chenodeoxycholate Is an Inhibitor of Clostridium difficile Spore Germination

被引：154

作者：

Sorg, Joseph A. ^{[1
]}

Sonenshein, Abraham L. ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 03期

基金：

美国国家卫生研究院;

关键词：

BILE-ACIDS; MECHANISM;

D O I：

10.1128/JB.01260-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.

引用

页码：1115 / 1117

页数：3

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