The keystone-pathogen hypothesis

被引：1228

作者：

Hajishengallis, George ^{[1
]}

Darveau, Richard P. ^{[2
]}

Curtis, Michael A. ^{[3
]}

机构：

[1] Univ Penn, Sch Dent Med, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Univ Washington, Sch Dent, Dept Periodont, Seattle, WA 98195 USA

[3] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, Ctr Immunol & Infect Dis, London E1 2AT, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2012年 / 10卷 / 10期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

BACTEROIDES-FRAGILIS ENTEROTOXIN; HUMAN GUT MICROBIOTA; PORPHYROMONAS-GINGIVALIS; INTESTINAL MICROBIOTA; COLORECTAL-CANCER; COMMENSAL MICROBIOTA; PERIODONTAL-DISEASE; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PREVOTELLA-INTERMEDIA; BACTERIAL COMMUNITY;

D O I：

10.1038/nrmicro2873

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent studies have highlighted the importance of the human microbiome in health and disease. However, for the most part the mechanisms by which the microbiome mediates disease, or protection from it, remain poorly understood. The keystone-pathogen hypothesis holds that certain low-abundance microbial pathogens can orchestrate inflammatory disease by remodelling a normally benign microbiota into a dysbiotic one. In this Opinion article, we critically assess the available literature that supports this hypothesis, which may provide a novel conceptual basis for the development of targeted diagnostics and treatments for complex dysbiotic diseases.

引用

页码：717 / 725

页数：9

共 86 条

[1] Monitoring Bacterial Community of Human Gut Microbiota Reveals an Increase in Lactobacillus in Obese Patients and Methanogens in Anorexic Patients [J].

Armougom, Fabrice ;

Henry, Mireille ;

Vialettes, Bernard ;

Raccah, Denis ;

Raoult, Didier .

PLOS ONE, 2009, 4 (09)

[2] Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut [J].

Artis, David .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :411-420

[3] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[4] The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? [J].

Azcarate-Peril, M. Andrea ;

Sikes, Michael ;

Bruno-Barcena, Jose M. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2011, 301 (03) :G401-G424

[5] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[6] Role of Porphyromonas gingivalis Phosphoserine Phosphatase Enzyme SerB in Inflammation, Immune Response, and Induction of Alveolar Bone Resorption in Rats [J].

Bainbridge, Brian ;

Verma, Raj K. ;

Eastman, Christie ;

Yehia, Bilal ;

Rivera, Mercedes ;

Moffatt, Catherine ;

Bhattacharyya, Indraneel ;

Lamont, Richard J. ;

Kesavalu, Lakshmyya .

INFECTION AND IMMUNITY, 2010, 78 (11) :4560-4569

[7] CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium [J].

Bry, L ;

Brigl, M ;

Brenner, MB .

INFECTION AND IMMUNITY, 2006, 74 (01) :673-681

[8] Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma [J].

Castellarin, Mauro ;

Warren, Rene L. ;

Freeman, J. Douglas ;

Dreolini, Lisa ;

Krzywinski, Martin ;

Strauss, Jaclyn ;

Barnes, Rebecca ;

Watson, Peter ;

Allen-Vercoe, Emma ;

Moore, Richard A. ;

Holt, Robert A. .

GENOME RESEARCH, 2012, 22 (02) :299-306

[9] The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases [J].

Chassaing, Benoit ;

Darfeuille-Michaud, Arlette .

GASTROENTEROLOGY, 2011, 140 (06) :1720-U40

[10] Persistent bacterial colonization of Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillus actinomycetemcomitans in periodontitis and its association with alveolar bone loss after 6 months of therapy [J].

Chaves, ES ;

Jeffcoat, MK ;

Ryerson, CC ;

Snyder, B .

JOURNAL OF CLINICAL PERIODONTOLOGY, 2000, 27 (12) :897-903

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