Similarity in form and function of the hippocampus in rodents, monkeys, and humans

被引:73
作者
Clark, Robert E. [1 ,2 ]
Squire, Larry R. [1 ,2 ,3 ,4 ]
机构
[1] Vet Affairs Med Ctr, San Diego, CA 92161 USA
[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
基金
美国国家科学基金会;
关键词
MEDIAL TEMPORAL-LOBE; IMPAIRED RECOGNITION MEMORY; NONMATCHING-TO-SAMPLE; OBJECT RECOGNITION; LESIONS; RATS; AMNESIA; DAMAGE; NEUROANATOMY; PERSPECTIVE;
D O I
10.1073/pnas.1301225110
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
We begin by describing an historical scientific debate in which the fundamental idea that species are related by evolutionary descent was challenged. The challenge was based on supposed neuroanatomical differences between humans and other primates with respect to a structure known then as the hippocampus minor. The debate took place in the early 1860s, just after the publication of Darwin's famous book. We then recount the difficult road that was traveled to develop an animal model of human memory impairment, a matter that also turned on questions about similarities and differences between humans and other primates. We then describe how the insight that there are multiple memory systems helped to secure the animal model and how the animal model was ultimately used to identify the neuroanatomy of long-term declarative memory (sometimes termed explicit memory). Finally, we describe a challenge to the animal model and to cross-species comparisons by considering the case of the concurrent discrimination task, drawing on findings from humans and monkeys. We suggest that analysis of such cases, based on the understanding that there are multiple memory systems with different properties, has served to emphasize the similarities in memory function across mammalian species.
引用
收藏
页码:10365 / 10370
页数:6
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