Metabolomics: A Global Biochemical Approach to the Study of Central Nervous System Diseases

被引：224

作者：

Kaddurah-Daouk, Rima ^{[1
]}

Krishnan, K. Ranga Rama ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2009年 / 34卷 / 01期

基金：

美国国家卫生研究院;

关键词：

metabolomics; pharmacometabolomics; metabonomics; biomarkers; neurodegenerative; psychiatric diseases; NEURONAL CEROID-LIPOFUSCINOSES; GAMMA-AMINOBUTYRIC-ACID; CEREBROSPINAL-FLUID; APOLIPOPROTEIN-E; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; TYPE-4; ALLELE; GENE; METABONOMICS; BIOMARKERS;

D O I：

10.1038/npp.2008.174

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Metabolomics, the omics science of biochemistry, is a global approach to understanding regulation of metabolic pathways and metabolic networks of a biological system. Metabolomics complements data derived from genomics, transcriptomics, and proteomics to assist in providing a systems approach to the study of human health and disease. In this review we focus on applications of metabolomics for the study of diseases of the nervous system. We share concepts in metabolomics, tools used in metabolic profiling and early findings from the study of neuropsychiatric diseases, and drugs used to treat these diseases. Metabolomics emerges as another powerful tool in central nervous system research.

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页码：173 / 186

页数：14

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