Diabetes, sarcopenia, and frailty

被引:143
作者
Morley, John E. [1 ]
机构
[1] St Louis VA Med Ctr, Geriatr Res Educ & Clin Ctr, St Louis, MO 63125 USA
关键词
D O I
10.1016/j.cger.2008.03.004
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 [法学]; 0303 [社会学]; 100203 [老年医学];
摘要
Frailty is a pre-disability condition. It now can be defined clinically. The major factors leading to frailty are sarcopenia and a decline in executive function. Stressors precipitate frail individuals into a state of disability. Diabetics develop the conditions necessary for frailty earlier than other aging individuals. Appropriate treatment of diabetes mellitus and frailty precursors can result in a slowing of the aging process.
引用
收藏
页码:455 / +
页数:16
相关论文
共 149 条
[1]
Inflammatory process in type 2 diabetes - The role of cytokines [J].
Alexandraki, Krystallenia ;
Piperi, Christina ;
Kalofoutis, Christos ;
Singh, Jaipaul ;
Alaveras, Antonis ;
Kalofoutis, Anastasios .
DIABETES MELLITUS AND ITS COMPLICATIONS: MOLECULAR MECHANISMS, EPIDEMIOLOGY, AND CLINICAL MEDICINE, 2006, 1084 :89-117
[2]
Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis [J].
Alonso, Nuria ;
Granada, Maria Luisa ;
Salinas, Isabel ;
Reverter, Jorge Luis ;
Flores, Lilliam ;
Ojanguren, Isabel ;
Martinez-Caceres, Eva Maria ;
Sanmarti, Anna .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2007, 157 (06) :763-769
[3]
Aoyama Linda, 2006, J Am Med Dir Assoc, V7, pS66, DOI 10.1016/j.jamda.2005.12.018
[4]
Banks WA, 2003, J GERONTOL A-BIOL, V58, P314
[5]
Insulin resistance syndrome in the elderly - Assessment of functional, biochemical, metabolic, and inflammatory status [J].
Banks, William A. ;
Willoughby, Lisa M. ;
Thomas, David R. ;
Morley, John E. .
DIABETES CARE, 2007, 30 (09) :2369-2373
[6]
Myostatin expression is not altered by insulin deficiency and replacement in streptozotocin-diabetic rat skeletal muscles [J].
Barazzoni, R ;
Zanetti, M ;
Bosutti, A ;
Stebel, M ;
Cattin, L ;
Biolo, G ;
Guarnieri, G .
CLINICAL NUTRITION, 2004, 23 (06) :1413-1417
[7]
Sarcopenic obesity predicts Instrumental Activities of Daily Living disability in the elderly [J].
Baumgartner, RN ;
Wayne, SJ ;
Waters, DL ;
Janssen, I ;
Gallagher, D ;
Morley, JE .
OBESITY RESEARCH, 2004, 12 (12) :1995-2004
[8]
Belgeri M, 2004, J GERONTOL A-BIOL, V59, P1025
[9]
Bhasin S, 2003, J GERONTOL A-BIOL, V58, P1103
[10]
Risk of fracture in women with type 2 diabetes: The Women's Health Initiative Observational Study [J].
Bonds, Denise E. ;
Larson, Joseph C. ;
Schwartz, Ann V. ;
Strotmeyer, Elsa S. ;
Robbins, John ;
Rodriguez, Beatriz L. ;
Johnson, Karen C. ;
Margolis, Karen L. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (09) :3404-3410