DNA methylation studies using twins: what are they telling us?

被引：49

作者：

Bell, Jordana T. ^{[1
]}

Spector, Tim D. ^{[1
]}

机构：

[1] Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England

来源：

GENOME BIOLOGY | 2012年 / 13卷 / 10期

基金：

欧洲研究理事会;

关键词：

Epigenetics; DNA methylation; twins; heritability; epigenome-wide association studies; EWAS; ALLELE-SPECIFIC METHYLATION; AUTISM SPECTRUM DISORDERS; MONOZYGOTIC TWINS; RHEUMATOID-ARTHRITIS; EXPRESSION VARIATION; GENETIC INFLUENCES; HUMAN GENOME; DISCORDANT; PAIRS; HERITABILITY;

D O I：

10.1186/gb-2012-13-10-172

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent studies have identified both heritable DNA methylation effects and differential methylation in disease-discordant identical twins. Larger sample sizes, replication, genetic-epigenetic analyses and longitudinal assays are now needed to establish the role of epigenetic variants in disease.

引用

页数：6

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