Classical twin studies and beyond

被引：757

作者：

Boomsma, D

Busjahn, A

Peltonen, L

机构：

[1] Free Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

[2] HealthTwiSt, D-13125 Berlin, Germany

[3] Charite, Franz Volhard Clin, D-13125 Berlin, Germany

[4] Univ Helsinki, Dept Med Genet, FIN-00290 Helsinki, Finland

[5] Univ Helsinki, Dept Mol Med, FIN-00290 Helsinki, Finland

[6] Natl Publ Hlth Inst, Biomedicum, Helsinki 00290, Finland

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 11期

关键词：

D O I：

10.1038/nrg932

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Twin studies have been a valuable source of information about the genetic basis of complex traits. To maximize the potential of twin studies, large, worldwide registers of data on twins and their relatives have been established. Here, we provide an overview of the current resources for twin research. These can be used to obtain insights into the genetic epidemiology of complex traits and diseases, to study the interaction of genotype with sex, age and lifestyle factors, and to study the causes of co-morbidity between traits and diseases. Because of their design, these registers offer unique opportunities for selected sampling for quantitative trait loci linkage and association studies.

引用

页码：872 / 882

页数：11

共 78 条

[1]

Genomewide scans of complex human diseases:: True linkage is hard to find [J].