Comparative rheomechanical and adhesive properties of two hydrocolloid dressings: Dependence on the degree of hydration

被引:20
作者
Ferrari, F
Bertoni, M
Rossi, S
Bonferoni, MC
Caramella, C
Waring, MJ
Aulton, ME
机构
[1] DE MONTFORT UNIV,DEPT PHARMACEUT SCI,LEICESTER LE1 9BH,LEICS,ENGLAND
[2] UNIV PAVIA,DEPT PHARMACEUT CHEM,I-27100 PAVIA,ITALY
[3] CONVATEC,WOUND HEALING RES INST,CLWYD,WALES
[4] DE MONTFORT UNIV,DEPT PHARMACEUT SCI,LEICESTER LE1 9BH,LEICS,ENGLAND
关键词
D O I
10.3109/03639049609063241
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Hydration is believed to modify the mechanical properties (resistance to stress) and the rheological (viscoelastic) properties of hydrocolloid dressings. Rheomechanical properties in turn influence adhesional properties. lit this work the relationships between the degree of hydration and the rheomechanical and the adhesive properties of two different commercial dressings (regular and nondispersive) were investigated. The two dressings showed different hydration characteristics. The regular dressing takes up water rapidly and tends to reach saturation after 12 hr. As the dressing swells and loses its integrity there is an accompanying reduction of both rheomechanical and adhesive properties. The nondispersive dressing exhibits a linear water uptake profile over extended periods of hydration up to 4 days. It does not swell and its rheomechanical and adhesive properties remain unchanged after hydration. The comparative evaluation of the results obtained with the various methods points to the relevance of mechanical and viscoelastic properties to the functionality assessment of dressings.
引用
收藏
页码:1223 / 1230
页数:8
相关论文
共 12 条
  • [11] QUEEN D, 1981, INT J PHARM, V44, P25
  • [12] THOMAS S, 1991, PHARM J, V247, P672