Investigation of bioisosters of the growth hormone secretagogue L-692,429.

被引：49

作者：

Ankersen, M ^{[1
]}

Peschke, B ^{[1
]}

Hansen, BS ^{[1
]}

Hansen, TK ^{[1
]}

机构：

[1] NOVO NORDISK AS,ASSAY & CELL TECHNOL,DK-2880 BAGSVAERD,DENMARK

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(97)00216-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and structure-activity relationships of several analogs of L-692,429 with modifications in the biaryl and tetrazole moieties are described and several derivatives were found to be equipotent or slightly more potent than L-692,429. (C) 1997 Elsevier Science Ltd.

引用

页码：1293 / 1298

页数：6

共 19 条

[1] ALLEN EE, 1993, Patent No. 5198438
[2] SEQUENTIAL DIRECTED ORTHO METALATION BORONIC ACID CROSS-COUPLING REACTIONS - A GENERAL REGIOSPECIFIC ROUTE TO OXYGENATED DIBENZO[B,D]PYRAN-6-ONES RELATED TO ELLAGIC ACID
ALO, BI
KANDIL, A
PATIL, PA
SHARP, MJ
SIDDIQUI, MA
SNIECKUS, V
JOSEPHY, PD
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (12) : 3763 - 3768
[3] NONPEPTIDE ANGIOTENSIN-II ANTAGONISTS - N-PHENYL-1H-PYRROLE DERIVATIVES ARE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
BOVY, PR
REITZ, DB
COLLINS, JT
CHAMBERLAIN, TS
OLINS, GM
CORPUS, VM
MCMAHON, EG
PALOMO, MA
KOEPKE, JP
SMITS, GJ
MCGRAW, DE
GAW, JF
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (01) : 101 - 110
[4] PALLADIUM-CATALYZED ALKYLATIONS IN AQUEOUS-MEDIA
CASALNUOVO, AL
CALABRESE, JC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (11) : 4324 - 4330
[5] ALIPHATIC REPLACEMENTS OF THE BIPHENYL MOIETY OF THE NONPEPTIDYL GROWTH-HORMONE SECRETAGOGUES L-692,429 AND L-692,585
CHU, L
MROZIK, H
FISHER, MH
BROWN, JE
CHENG, K
CHAN, WWS
SCHOEN, WR
WYVRATT, MJ
BUTLER, BS
SMITH, RG
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (19) : 2245 - 2250
[6] BENZOLACTAM GROWTH-HORMONE SECRETAGOGUES - CARBOXAMIDES AS REPLACEMENTS FOR THE 2'-TETRAZOLE MOIETY OF L-692,429
DEVITA, RJ
SCHOEN, WR
FISHER, MH
FRONTIER, AJ
PISANO, JM
WYVRATT, MJ
CHENG, K
CHAN, WWS
BUTLER, BS
HICKEY, GJ
JACKS, TM
SMITH, RG
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (18) : 2249 - 2254
[7] Devita Robert J., 1996, Drugs of the Future, V21, P273
[8] GROWTH-HORMONE RESPONSE IN MAN TO L-692,429, A NOVEL NONPEPTIDE MIMIC OF GROWTH HORMONE-RELEASING PEPTIDE-6
GERTZ, BJ
BARRETT, JS
EISENHANDLER, R
KRUPA, DA
WITTREICH, JM
SEIBOLD, JR
SCHNEIDER, SH
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (05) : 1393 - 1397
[9] AN EXTREMELY SENSITIVE INVITRO MODEL FOR ELUCIDATING STRUCTURE-ACTIVITY-RELATIONSHIPS OF GROWTH HORMONE-RELEASING FACTOR ANALOGS
HEIMAN, ML
NEKOLA, MV
MURPHY, WA
LANCE, VA
COY, DH
[J]. ENDOCRINOLOGY, 1985, 116 (01) : 410 - 415
[10] A receptor in pituitary and hypothalamus that functions in growth hormone release
Howard, AD
Feighner, SD
Cully, DF
Arena, JP
Liberator, PA
Rosenblum, CI
Hamelin, M
Hreniuk, DL
Palyha, OC
Anderson, J
Paress, PS
Diaz, C
Chou, M
Liu, KK
McKee, KK
Pong, SS
Chaung, LY
Elbrecht, A
Dashkevicz, M
Heavens, R
Rigby, M
Sirinathsinghji, DJS
Dean, DC
Melillo, DG
Patchett, AA
Nargund, R
Griffin, PR
DeMartino, JA
Gupta, SK
Schaeffer, JM
Smith, RG
VanderPloeg, LHT
[J]. SCIENCE, 1996, 273 (5277) : 974 - 977

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