Fluorescence Signal Amplification by Cation Exchange in Ionic Nanocrystals

被引:59
作者
Li, Jishan [1 ]
Zhang, Tierui [1 ]
Ge, Jianping [1 ]
Yin, Yadong [1 ]
Zhong, Wenwan [1 ]
机构
[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA
关键词
fluorescence; ion exchange; ionic nanocrystals; sensors; signal amplification; QUANTUM DOTS; CALCIUM; SENSORS; BIOSENSORS; RHOD-5N; AGENTS;
D O I
10.1002/anie.200805710
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) Lighting-up time: A cation-exchange reaction releases thousands of divalent cations from nonfluorescent CdSe ionic crystals and triggers fluorescence of originally nonfluorescent Fluo-4 fluorophores to obtain a large fluorescence amplification (see picture) and a low detection limit in bioassays. simple, with a large dye-to-reporter labeling ratio, and flexible in selection of nanocrystals and fluorophores. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:1588 / 1591
页数:4
相关论文
共 26 条
[1]   Metal-enhanced fluorescence: an emerging tool in biotechnology [J].
Aslan, K ;
Gryczynski, I ;
Malicka, J ;
Matveeva, E ;
Lakowicz, JR ;
Geddes, CD .
CURRENT OPINION IN BIOTECHNOLOGY, 2005, 16 (01) :55-62
[2]   Mesoporous silica templated biolabels with releasable fluorophores for immurroassays [J].
Cai, Wenyi ;
Gentle, Ian R. ;
Lu, Gao Qing ;
Zhu, Jun-Jie ;
Yu, Aimin .
ANALYTICAL CHEMISTRY, 2008, 80 (14) :5401-5406
[3]   Optimization of fluorescence response in the design of molecular biosensors [J].
Demchenko, AP .
ANALYTICAL BIOCHEMISTRY, 2005, 343 (01) :1-22
[4]   Synthetic fluorescent sensors for studying the cell biology of metals [J].
Domaille, Dylan W. ;
Que, Emily L. ;
Chang, Christopher J. .
NATURE CHEMICAL BIOLOGY, 2008, 4 (03) :168-175
[5]   Highly sensitive biomolecular fluorescence detection using nanoscale ZnO platforms [J].
Dorfman, Adam ;
Kumar, Nitin ;
Hahm, Jong-in .
LANGMUIR, 2006, 22 (11) :4890-4895
[6]   The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands [J].
Dufner, MM ;
Kirchhoff, P ;
Remy, C ;
Hafner, P ;
Müller, MK ;
Cheng, SX ;
Tang, LQ ;
Hebert, SC ;
Geibel, JP ;
Wagner, CA .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 289 (06) :G1084-G1090
[7]   Technological advancements for the detection of and protection against biological and chemical warfare agents [J].
Eubanks, Lisa M. ;
Dickerson, Tobin J. ;
Janda, Kim D. .
CHEMICAL SOCIETY REVIEWS, 2007, 36 (03) :458-470
[8]   Direct optical sensors: principles and selected applications [J].
Gauglitz, G .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2005, 381 (01) :141-155
[9]   A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors [J].
Gopalakrishnan, SM ;
Moreland, RB ;
Kofron, JL ;
Helfrich, RJ ;
Gubbins, E ;
McGowen, J ;
Masters, JN ;
Donnelly-Roberts, D ;
Brioni, JD ;
Burns, DJ ;
Warrior, U .
ANALYTICAL BIOCHEMISTRY, 2003, 321 (02) :192-201
[10]   Photostability of luminescent water-soluble cadmium selenide nanocrystals with chemical surface modification [J].
Gurinovich L.I. ;
Artem'ev M.V. ;
Lyutich A.A. ;
Gaponenko S.V. .
Journal of Applied Spectroscopy, 2006, 73 (4) :572-575