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The stoichiometry of expression of protein components of the stimulatory adenylyl cyclase cascade and the regulation of information transfer

被引：34
作者：
Milligan, G
机构：
来源：
CELLULAR SIGNALLING | 1996年 / 8卷 / 02期
基金：
英国惠康基金;
关键词：
receptor; G protein; adenylyl cyclase;
D O I：
10.1016/0898-6568(95)02034-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Quantitative analysis of the proteins which compromise the stimulatory arm of the adenylyl cyclase cascade indicate that the adenylyl cyclase catalytic component is usually the least highly expressed. The effects on both potency of agonist ligands and maximal output resulting from targetted alterations in expression levels of each element of this cascade are discussed.
引用
收藏
页码：87 / 95
页数：9
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