Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus

被引：105

作者：

Hu, ZQ

Zhao, WH

Asano, N

Yoda, Y

Hara, Y

Shimamura, T

机构：

[1] Showa Univ, Sch Med, Dept Microbiol & Immunol, Shinagawa Ku, Tokyo 1428555, Japan

[2] Tokyo Food Techno Co Ltd, Tokyo, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 02期

关键词：

D O I：

10.1128/AAC.46.2.558-560.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Combinations of carbapenems and epigallocatechin gallate (EGCg; a main constituent of tea catechins) showed potent synergy against 24 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). MICs of imipenem in the presence of EGCg at 3.125, 6.25, 12.5, and 25 mug/ml, were restored to the susceptible breakpoint (less than or equal to4 mug/ml) for 8, 38, 46, and 75% of the MRSA isolates, respectively. Similar results were also observed for combinations of panipenem or meropenem and EGCg. Therefore, the combinations may be worthy of further evaluation in vivo against MRSA infection.

引用

页码：558 / 560

页数：3

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