Analysis of residual products in benzalkonium chloride by high-performance liquid chromatography

被引：9

作者：

Prieto-Blanco, MC

López-Mahía, P ^{[1
]}

Prada-Rodríguez, D

机构：

[1] Univ A Coruna, Fac Sci, Dept Analyt Chem, A Coruna 15071, Spain

[2] Arteixo Quim SL Lab Qual Control, Arteixo 15432, A Coruna, Spain

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1999年 / 37卷 / 08期

关键词：

D O I：

10.1093/chromsci/37.8.295

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method for the separation of the homologous series of benzalkonium chloride (BAK), benzyl chloride, and possible byproducts is presented. Under recommended conditions, 2 mobile phases (isocratic and gradient elutions, depending on the impurities present) are proposed. A study of the kinetics of the removal of benzyl chloride under different conditions (catalyst, excess of amine, different solvents) allows the synthesis of BAK without residual benzyl chloride.

引用

页码：295 / 299

页数：5

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