A new two-step four-component synthesis of highly functionalized cyclohexenols by sequential nickel-catalyzed couplings

被引：47

作者：

Lozanov, M ^{[1
]}

Montgomery, J ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 10期

关键词：

D O I：

10.1021/ja0175845

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new two-step procedure for the synthesis of cyclohexenols has been developed. A nickel-catalyzed three-component addition of an enal, alkyne, and acetylenic tin affords substituted hept-4-en-6-ynals. The products of this first step then undergo a second nickel-catalyzed reaction with organozincs or organoboranes to afford densely functionalized cyclohexenols. Variation in each of the four components is tolerated to provide access to a wide range of versatile building blocks. Copyright © 2002 American Chemical Society.

引用

页码：2106 / 2107

页数：2

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