The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis

被引：63

作者：

Feldmann, M ^{[1
]}

Brennan, FM ^{[1
]}

Williams, RO ^{[1
]}

Woody, JN ^{[1
]}

Maini, RN ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Kennedy Inst, Div Rheumatol, London W6 8LH, England

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2004年 / 18卷 / 01期

基金：

英国惠康基金;

关键词：

cytokine; therapy; antibody; anti-TNF;

D O I：

10.1016/j.berh.2003.09.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made.

引用

页码：59 / 80

页数：22

共 75 条

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