Structure-activity relationship for human cytochrome P450 substrates and inhibitors

被引：71

作者：

Lewis, DFV ^{[1
]}

Modi, S

Dickins, M

机构：

[1] Univ Surrey, Sch Biomed & Life Sci, Surrey GU2 7XH, England

[2] GlaxoSmithKline Res & Dev Ltd, Ware SG12 0DP, Herts, England

来源：

DRUG METABOLISM REVIEWS | 2002年 / 34卷 / 1-2期

关键词：

D O I：

10.1081/DMR-120001391

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Criteria governing the avidity of substrate binding to human hepatic cytochromes P450 (CYP) associated with Phase 1 metabolism of drugs are described. The results of extensive quantitative structure-activity relationship (QSAR) analyses are reported for substrates of human P450s: CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4, representing the enzymes exhibiting major involvement in the metabolism of drug substrates in Homo sapiens. In particular, it is shown that hydrogen bond properties in each class of enzyme-substrate complex are especially important factors in determining substrate binding affinity towards those human P450s which are involved in drug metabolism.

引用

页码：69 / 82

页数：14

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