Thin filament-mediated regulation of cardiac contraction

被引:391
作者
Tobacman, LS [1 ]
机构
[1] UNIV IOWA,DEPT BIOCHEM,IOWA CITY,IA 52242
关键词
troponin; tropomyosin; muscle proteins; cooperativity; actin;
D O I
10.1146/annurev.ph.58.030196.002311
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Cardiac and skeletal muscle contraction are activated by Ca2+ binding to specific regulatory sites on the striated muscle thin filament. The thin filament is a large allosteric assembly, containing multiple copies of actin, tropomyosin, and the three troponin subunits (troponin C, troponin I, and troponin T). This review describes recent developments in understanding the structure and dynamics of these proteins and how they function to regulate contraction. Emphasis is placed on the cardiac thin filament and on the features that distinguish it from the skeletal muscle system. The discussion also emphasizes current knowledge of the protein-protein interactions involved in the cooperative processes of thin filament assembly and regulation.
引用
收藏
页码:447 / 481
页数:35
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